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. Author manuscript; available in PMC: 2011 Oct 21.
Published in final edited form as: J Theor Biol. 2010 Jun 25;266(4):625–640. doi: 10.1016/j.jtbi.2010.06.027

Figure 1.

Figure 1

Mechanisms underlying fluid flow. The basal membrane separates the cytoplasm from the interstitium, with the apical membrane at the other pole separating the cytoplasm from the lumen. Cl− moves into the lumen through the apical membrane and water follows by osmosis. Paracellular movement of cations through the tight junctions balances the movement of negative Cl− ions into lumen. The model allows for the possibility of apical as well as basal K+ channels. We also allow for possible Cl− efflux through the basal membrane.