Figure 6.

Effect of blocking the Ryanodine receptor in the model (a) by setting k_RyR = 0 and (b) experimentally by applying a large (500 µM) Ryanodine concentration. Ca²⁺ oscillations are initiated in the model by setting ν = 5100 nM/s, and experimentally by adding 300 nM carbachol at the times shown with the horizontal bars. With the exception of the period when k_RyR = 0 all the model parameters are those found in Table 3. Experimental ‘ratio unit’ represents the fluorescence of fura-2 and gives a measure for Ca²⁺ concentration. Experimental trace reproduced from Bruce et al. (2002) with permission from the authors.