Table 3.
Ca2+ parameters | ||||||||
---|---|---|---|---|---|---|---|---|
kIPR | 0.04 s−1 | kRyR | 0.01 s−1 | ker | 1.554 × 10−4 s−1 | |||
VSERCA | 1 × 10−9 nmol s−1 | KSERCA | 400 nM* | |||||
Vpm | 15 × 10−12 nmol s−1 | Kpm | 200 nM ** | |||||
α1 | 2.31 × 10−13 nmol s−1 | α2 | 3.5 × 10−4 s−1 | |||||
w0/wer | 5.405 | |||||||
RyR parameters # | ||||||||
|
1500 (µM)−4 s−1 |
|
1500 (µM)−3 s−1 |
|
1.75 s−1 | |||
|
28.8 s−1 |
|
385.9 s−1 |
|
0.1 s−1 | |||
Ka | 372 nM | Kb | 636 nM | Kc | 0.0057 |
parameters from Keizer and Levine (1996),
from Lytton et al. (1992),
taken from Camello et al. (1996), all remaining receptor densities and parameters are fitted to recreate experimental Ca2+ oscillations.