Table 1.
Binding affinities of investigated opioid compounds at μ, δ and κ opioid receptors.
|
Ki (nM)a |
|||
|---|---|---|---|
| [3H]DAMGO (μ)b | [3H][Ile5,6]deltorphin II (δ)b | [3H]U69,593 (κ)c | |
| 1 | 0.31 ± 0.02 | 13.1 ± 1.7 | 22.8 ± 0.3 |
| 3 | 34.1 ± 6.0 | >10,000 | 1894 ± 453 |
| 4 | 65.4 ± 2.9 | >10,000 | 4414 ± 1229 |
| 14-MMd | 0.15 ± 0.01 | 13.3 ± 0.2 | 25.2 ± 4.9b |
| 14-OMOe | 0.10 ± 0.01 | 4.80 ± 0.22 | 10.2 ± 2.0b |
| Morphined | 6.55 ± 0.74 | 217 ± 19 | 113 ± 9b |
a
Values are the mean ± SEM of 2–6 independent experiments, all performed in duplicate.
b
Rat brain membranes were used.
c
Guinea brain membranes were used.
d
Data from Spetea et al. (2003).
e
Data from Spetea et al. (2004a).