Table 2.

Stimulation of [³⁵S]GTPγS binding in response to investigated opioid compounds in rat brain membranes.

	ED50 (nM)a	Emax (%)a
1	13.7 ± 2.6d	158 ± 2c
14-MM	63.0 ± 6.3d,g	203 ± 13f
14-OMO	23.7 ± 2.0d,e	199 ± 5f
Morphine	462 ± 42f	157 ± 6b
DAMGO	309 ± 35	185 ± 4

^aValues are the mean ± SEM of at least three independent experiments, all performed in triplicate.

^bp < 0.05.

^cp < 0.01.

^dp < 0.001 vs. DAMGO.

^ep < 0.05.

^fp < 0.01.

^gp < 0.001 vs. compound 1.