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A schematic of CTLA-4 self-association. (a) Schematic of the native, membrane-bound disulfide-bonded CTLA-4 dimer on a membrane (wavy line), (b) the dimeric structure reported here (compare Fig. 1a), and (c) a possible arrangement of five subunits within a CTLA-4 amyloid fiber according to a matching strand swapping.
