Table 1.
IOP Data
| MEAN ± SD | MEAN ± SD | MEAN ± SD | Median IOP | Positive | Average # | Percent IOP | |||
|---|---|---|---|---|---|---|---|---|---|
| Strain | n | Duration | RE IOP (mmHg) | LE IOP (mmHg) | IOP diff (mmHg) | diff LE-RE (mmHg) | Integral | IOP elevations | elevations |
| C57/BL6 younger | 9 | 3 weeks | 11.2 ± 1.1 | 26.3 ± 7.6 | 15.1 ± 7.6 | 18 | 231 ± 144.7 | 2.4 ± 0.9 | 70% ± 26% |
| C57/BL6 younger | 27 | 6 weeks | 9.8 ± 1.1 | 15.3 ± 4.6 | 5.5 ± 4.2 | 5 | 196 ± 158.7 | 3.3 ± 2.0 | 47% ± 29% |
| C57/BL6 younger | 13 | 12 weeks | 9.8 ± 1.0 | 14.4 ± 4.0 | 4.7 ± 3.8 | 5 | 397 ± 260.4 | 5.5 ± 2.4 | 40%± 21% |
| C57/BL6 older | 12 | 6 weeks | 9.8 ± 1.3 | 14.5 ± 4.0 | 4.8 ± 4.5 | 4 | 179 ± 152.9 | 2.8 ± 2.3 | 39% ± 32% |
| C57/BL6 older | 12 | 12 weeks | 11.2 ± 0.8 | 16.4 ± 2.5 | 5.3 ± 2.6 | 5 | 421 ± 234.8 | 6.8 ± 3.1 | 61% ± 24% |
| DBA/2J younger | 12 | 6 weeks | 11.1 ± 1.0 | 14.9 ± 1.5 | 3.8 ± 1.3 | 3 | 142 ± 76.0 | 2.9 ± 1.3 | 42% ± 19% |
| DBA/2J younger | 13 | 12 weeks | 10.7 ± 0.9 | 13.0 ± 2.6 | 3.1 ± 3.1 | 2 | 226 ± 254.2 | 3.1 ± 3.1 | 24% ± 24% |
| CD1 younger | 10 | 6 weeks | 10.3 ± 0.8 | 11.8 ± 2.0 | 1.5 ± 2.5 | 1.5 | 68 ± 55.4 | 1.5 ± 1.0 | 21% ± 14% |
| CD1 younger | 11 | 12 weeks | 10.3 ± 0.8 | 13.5 ± 3.2 | 3.2 ± 3.5 | 2 | 255 ± 265.5 | 4.4 ± 3.2 | 34% ± 25% |
| Total | 119 | 42% |
Mean and median intraocular pressures (IOP, in mmHg) for right eye (RE) and left eye (LE), diff = difference LE-RE, positive integral IOP (see explanation in Methods), number of IOP elevations throughout study duration, and IOP percent elevations of all measurements. Elevation defined as exceeding the 97.5% confidence interval for interocular IOP difference in normal mice (5 mmHg). Values are given as mean ± standard deviation, except for median IOP difference LE-RE. Sample number (N)