Table 2.
Axial length and width changes with induced IOP elevation.
| Control eyes | Bead eyes | Increase | Increase | % length | |||||
|---|---|---|---|---|---|---|---|---|---|
| Strain | Weeks | N | Length | Width | Length | Width | Length | Width | change (P) |
| C57/BL6 younger | 6 | 27 | 3.32 ± 0.15 | 3.21 ± 0.15 | 3.77 ± 0.33 | 3.47 ± 0.49 | 13.6% | 8.1% | <0.0001 |
| C57/BL6 older | 6 | 12 | 3.43 ± 0.10 | 3.23 ± 0.13 | 3.60 ± 0.22 | 3.47 ± 0.19 | 5.2% | 6.7% | 0.02 |
| C57/BL6 older | 12 | 12 | 3.68 ± 0.10 | 3.44 ± 0.12 | 3.99 ± 0.35 | 3.68 ± 0.22 | 8.3% | 6.9% | 0.007 |
| CD1 | 6 | 10 | 3.56 ± 0.11 | 3.32 ± 0.09 | 3.80± 0.20 | 3.51 ± 0.13 | 6.8% | 5.9% | <0.0001 |
| CD1 | 12 | 11 | 3.58 ± 0.09 | 3.47 ± 0.12 | 3.73 ± 0.25 | 3.63 ± 0.25 | 4.3% | 4.6% | 0.08 |
| DBA/2J younger | 6 | 12 | 3.35 ± 0.08 | 3.25 ± 0.12 | 4.19 ± 0.26 | 3.65 ± 0.21 | 25.3% | 12.4% | <0.0001 |
| DBA/2J younger | 12 | 13 | 3.50 ± 0.10 | 3.29 ± 0.11 | 3.80 ± 0.18 | 3.59 ± 0.16 | 8.7% | 8.3% | <0.0001 |
| DBA/2J older | 50 | 55 | 3.83 ± 0.23 | 3.69 ± 0.27 | 14.3% | 13.5% | <0.0001 |
Length and width values are mean ± standard deviation; included here are axial length measurements from spontaneous glaucoma, DBA/2J older mice (mean age 55 weeks) compared to younger DBA/2J uninjected eyes; p values from t tests. Sample number (N)