Table 3.

Treatment of RBD

	Medication	Dosage/Timing	Side Effects
First line	Clonazepam	0.25–4.0 mg nightly, with dosages 0.5–2.0 most commonly used	Sedation, confusion
Second line	Melatonin	3 mg starting dose, titrated to 12 mg as needed. Taken 30 minutes before bedtime	Morning sleepiness, morning headaches
Other (medications with conflicting reports of efficacy or those supported by only single case reports)	Pramipexole, levodopa, sodium oxybate, zopiclone, carbamazepine desipramine, clonidine, donepezil, rivastigmine

Safety measures to protect the patient and bed-partner (i.e., modifications to the sleep environment) should always be considered, whether or not medication is implemented.