TABLE 3.
Baseline demographic, clinical, and laboratory values in 391 male maintenance hemodialysis patients at the start of the 5-y cohort study, by fat mass (FM) quartile1
| FM quartiles |
|||||
| 1 (n = 102) | 2 (n = 94) | 3 (n = 100) | 4 (n = 95) | P for trend2 | |
| Age (y) | 56 ± 163 | 55 ± 15 | 55 ± 14 | 51 ± 14 | <0.01 |
| Race (% African American) | 14 | 25 | 42 | 57 | 0.77 |
| Ethnicity (% Hispanic) | 67 | 61 | 42 | 53 | 0.59 |
| Primary insurance (% receiving Medicare) | 42 | 53 | 55 | 60 | 0.02 |
| Diabetes mellitus (%) | 49 | 57 | 56 | 59 | <0.01 |
| Marital status (% married) | 41 | 44 | 36 | 26 | <0.01 |
| Charlson comorbidity score | 1.8 ± 1.5 | 1.6 ± 1.5 | 2.0 ± 1.6 | 2.0 ± 1.7 | <0.01 |
| BMI (kg/m2) | 22.1 ± 4.0 | 25.1 ± 3.5 | 28.7 ± 4.1 | 34.0 ± 6.6 | <0.01 |
| Triceps-skinfold thickness (mm) | 16.1 ± 6.0 | 19.9 ± 7.7 | 23.7 ± 9.0 | 29.9 ± 10.7 | <0.01 |
| Biceps-skinfold thickness (mm) | 8.8 ± 5.0 | 10.3 ± 5.7 | 12.2 ± 6.4 | 18.6 ± 10.9 | <0.01 |
| MAMC (cm) | 21.9 ± 3.0 | 24.3 ± 4.4 | 26.1 ± 3.7 | 25.9 ± 5.0 | <0.01 |
| NIR interactance–measured body fat (%) | 28.9 ± 6.6 | 32.3 ± 6.4 | 36.4 ± 7.0 | 39.3 ± 6.6 | <0.01 |
| NIR interactance–measured FM (kg) | 6.0 ± 2.0 | 11.2 ± 1.4 | 16.2 ± 1.8 | 28.5 ± 9.3 | <0.01 |
| NIR interactance–measured LBM (kg) | 53.9 ± 7.9 | 56.6 ± 7.1 | 58.9 ± 6.5 | 65.3 ± 8.7 | <0.01 |
| Dialysis vintage (mo) | 29.0 ± 30.1 | 26.5 ± 23.1 | 31.5 ± 29.9 | 29.9 ± 25.9 | 0.87 |
| Dialysis dose, single pool (Kt/V) | 1.9 ± 0.3 | 1.8 ± 0.3 | 1.6 ± 0.3 | 1.6 ± 0.2 | 0.02 |
| nPNA (kg/d) | 1.11 ± 0.24 | 1.06 ± 0.19 | 1.03 ± 0.22 | 1.01 ± 0.21 | 0.58 |
| Serum albumin (mg/dL) | 3.82 ± 0.34 | 3.82 ± 0.34 | 3.86 ± 0.33 | 3.80 ± 0.26 | 0.04 |
| Prealbumin (mg/dL) | 26.9 ± 9.0 | 26.9 ± 8.5 | 29.2 ± 9.2 | 27.5 ± 9.1 | 0.83 |
| Creatinine (mg/dL) | 8.4 ± 2.4 | 9.4 ± 2.6 | 9.4 ± 2.9 | 10.6 ± 3.2 | <0.01 |
| C-reactive protein (mg/L) | 4.4 ± 4.9 | 4.4 ± 4.8 | 6.3 ± 6.6 | 6.8 ± 7.1 | <0.01 |
| IL-6 (pg/mL) | 11.5 ± 14.3 | 9.1 ± 8.4 | 12.8 ± 12.5 | 12.6 ± 17.2 | 0.02 |
| TNF-α (pg/mL) | 9.0 ± 7.7 | 8.4 ± 7.2 | 8.9 ± 13.7 | 9.7 ± 11.2 | 0.92 |
1
NIR, near-infrared; IL-6, interleukin-6; TNF-α, tumor necrosis factor-α; LBM, lean body mass; MAMC, midarm muscle circumference; nPNA, total nitrogen appearance normalized to body weight; Kt/V, urea clearance over time.
2
P values for triceps- and biceps-skinfold thicknesses, dialysis dose (vintage), C-reactive protein, IL-6, and TNF-α are based on the logarithmic values of these measures (ANOVA).
3
Mean ± SD (all such values).