TABLE 5.
Baseline demographic, clinical, and laboratory values in 351 maintenance hemodialysis women at the start of the 5-y cohort study according to their fat mass (FM) quartiles1
| FM quartiles |
|||||
| 1 (n = 89) | 2 (n = 96) | 3 (n = 80) | 4 (n = 86) | P for trend2 | |
| Age (y) | 50 ± 183 | 57 ± 15 | 56 ± 14 | 56 ± 11 | 0.05 |
| Race (% African American) | 30 | 21 | 37 | 49 | <0.01 |
| Ethnicity (% Hispanic) | 57 | 59 | 49 | 30 | <0.01 |
| Primary insurance (% receiving Medicare) | 43 | 52 | 58 | 59 | 0.06 |
| Diabetes mellitus (%) | 39 | 62 | 50 | 70 | <0.01 |
| Marital status (% married) | 35 | 44 | 37 | 30 | 0.35 |
| Charlson comorbidity score | 1.5 ± 1.7 | 1.9 ± 1.4 | 1.7 ± 1.6 | 2.3 ± 1.5 | <0.01 |
| BMI (kg/m2) | 20.5 ± 2.4 | 24.9 ± 2.0 | 28.6 ± 2.2 | 35.9 ± 5.1 | <0.01 |
| Triceps-skinfold thickness (mm) | 14.7 ± 6.1 | 19.2 ± 5.6 | 24.6 ± 8.1 | 31.0 ± 10.6 | <0.01 |
| Biceps-skinfold thickness (mm) | 7.9 ± 5.1 | 9.6 ± 5.4 | 13.1 ± 5.8 | 19.3 ± 10.3 | <0.01 |
| MAMC (cm) | 21.6 ± 4.1 | 23.7 ± 2.8 | 26.4 ± 3.4 | 29.2 ± 4.6 | <0.01 |
| NIR interactance–measured body fat (%) | 24.6 ± 5.1 | 32.2 ± 2.8 | 37.1 ± 2.8 | 43.3 ± 2.7 | <0.01 |
| NIR interactance–measured FM (kg) | 12.4 ± 3.1 | 19.9 ± 2.0 | 27.0 ± 2.3 | 41.0 ± 7.7 | <0.01 |
| NIR interactance–measured LBM (kg) | 37.9 ± 4.8 | 41.8 ± 5.4 | 45.9 ± 4.8 | 53.3 ± 7.4 | <0.01 |
| Dialysis vintage (mo) | 32 ± 31 | 25 ± 24 | 33 ± 26 | 27 ± 26 | 0.77 |
| Dialysis dose, single pool (Kt/V) | 1.8 ± 0.3 | 1.8 ± 0.3 | 1.7 ± 0.2 | 1.5 ± 0.3 | <0.01 |
| nPNA (kg/d) | 1.10 ± 0.22 | 1.06 ± 0.22 | 1.05 ± 0.20 | 1.02 ± 0.22 | 0.02 |
| Serum albumin (mg/dL) | 3.85 ± 0.36 | 3.80 ± 0.33 | 3.86 ± 0.31 | 3.79 ± 0.26 | 0.33 |
| Prealbumin (mg/dL) | 27.5 ± 19.1 | 26.9 ± 7.9 | 28.5 ± 9.0 | 27.4 ± 9.0 | 0.56 |
| Creatinine (mg/dL) | 9.4 ± 2.8 | 9.0 ± 2.6 | 10.1 ± 2.8 | 9.5 ± 3.2 | 0.33 |
| C-reactive protein (mg/L) | 3.8 ± 4.8 | 4.9 ± 5.3 | 5.9 ± 5.7 | 7.1 ± 7.3 | <0.01 |
| IL-6 (pg/mL) | 9.0 ± 11.2 | 12.1 ± 14.0 | 10.5 ± 8.7 | 13.9 ± 17.6 | 0.01 |
| TNF-α (pg/mL) | 7.1 ± 5.1 | 8.7 ± 8.9 | 8.7 ± 11.7 | 9.7 ± 13.2 | 0.61 |
1
NIR, near-infrared; IL-6, interleukin-6; TNF-α, tumor necrosis factor-α; LBM, lean body mass; MAMC, midarm muscle circumference; nPNA, total nitrogen appearance normalized to body weight; Kt/V, urea clearance over time.
2
P values for triceps- and biceps-skinfold thicknesses, dialysis dose (vintage), C-reactive protein, IL-6, and TNF-α are based on the logarithmic values of these measures (ANOVA).
3
Mean ± SD (all such values).