TABLE 2.

Body composition and resting metabolic rate (RMR) before and after 28 d of placebo or dihydrocapsiate ingestion¹

	Placebo (n = 28)		3 mg dihydrocapsiate (n = 25)		9 mg dihydrocapsiate (n = 25)		Effect (P value)
	Day 0	Day 28	Day 0	Day 28	Day 0	Day 28	Acute	Chronic	Dose
Fat-free mass (kg)	67.6 ± 1.8	67.7 ± 1.8	69.5 ± 1.5	69.9 ± 1.5	66.8 ± 1.4	67.1 ± 1.4	—	0.07	0.47
Fat mass (kg)	23.4 ± 1.4	23.7 ± 1.4	22.9 ± 1.2	23.2 ± 1.1	24.0 ± 1.3	24.4 ± 1.3	—	0.002	0.81
RMR
Before pill ingestion (kcal/d)	1714 ± 41	1700 ± 43	1760 ± 41	1792 ± 39	1694 ± 38	1723 ± 35	0.003	0.19	0.22
After pill ingestion (kcal/d)	1717 ± 40	1716 ± 37	1800 ± 39	1817 ± 42	1749 ± 31	1755 ± 39
Acute thermogenic effect (kcal/d)	3 ± 24	17 ± 19	41 ± 17	25 ± 21	55 ± 17	31 ± 16	—	0.56	0.27
Total AUC (kcal × min/d)	205,654 ± 4713	205,637 ± 4511	215,481 ± 4670	217,217 ± 4952	207,931 ± 4079	210,107 ± 4535	—	0.43	0.21
Nonprotein RQ
Before pill ingestion	0.84 ± 0.01	0.85 ± 0.01	0.83 ± 0.01	0.85 ± 0.01	0.83 ± 0.01	0.85 ± 0.01	<0.001	<0.0001	0.73
After pill ingestion	0.83 ± 0.01	0.84 ± 0.01	0.82 ± 0.01	0.84 ± 0.01	0.83 ± 0.01	0.83 ± 0.01
Total AUC (min)	100 ± 1	101 ± 1	99 ± 1	101 ± 1	99 ± 1	100 ± 1	—	0.005	0.79
Fat oxidation (g/d)
Before pill ingestion	68 ± 5	60 ± 5	72 ± 5	67 ± 6	68 ± 7	65 ± 6	<0.001	0.002	0.44
After pill ingestion	74 ± 4	69 ± 5	83 ± 5	75 ± 5	76 ± 5	77 ± 5
Total AUC (g × min/d)	8831 ± 482	8189 ± 539	9854 ± 563	8876 ± 634	8749 ± 604	9077 ± 613	—	0.20	0.47

¹All values are means ± SEs. RQ, respiratory quotient; AUC, area under the curve after pill ingestion. Metabolic variables were analyzed with the mixed model. Data were analyzed by using covariance analysis (PROC MIXED; SAS Institute, Cary, NC) with dose (0, 3, and 9 mg), acute consumption (before or after taking pill), and chronic consumption (days 1 and 28) and their interactions as fixed effects, whereas the subject nested within dose was the random effect. Fat and fat-free masses used similar analyses without acute effect.