. Author manuscript; available in PMC: 2011 Jun 1.

Published in final edited form as: Biochemistry. 2010 Jun 1;49(21):4440–4449. doi: 10.1021/bi100394j

Table 3.

Summary of important phenotypic characteristics

Residue alteration	IC₅₀ (μM cyh)	Δ¹	IC₅₀ (μM clo)	Δ	V_max (ATPase)	Δ
WT	7.50		22.5		222

S558Y	0.43	17.4	1.11	20.3	74.8²	2.9

S558Y, N242K²	4.10	1.8	Not done		88.9	2.5
S558Y, E244G	3.75	2.0	8.25	2.7	82.4	2.7
N242K	3.75	2.0	15.0	1.5	144	1.6
E244G	2.93	2.6	17.5	1.3	58.5	3.8
Q951G	3.90	1.9	6.78	3.4	57.3	3.7
E244G, Q951G	1.10	6.8	2.92	7.7	61.0	3.6

Δ value is the fold-difference between the particular mutant and the WT

Data are from (6)