Table 1.
Control (n = 4) | Early OA (n = 11) | Late OA (n = 18) | |
---|---|---|---|
Age | 43 ± 9.6 | 61 ± 17.4 | 60 ± 8.1 |
BMI | 30.5 ± 6.5 | 33.8 ± 8.2 | 33 ± 6.8 |
MPO (ng/ml) | −(0.04) ± 1.86 | 4.08 ± 1.43a,b | 0.24 ± 1.40 |
MPO levels obtained by ELISA in 33 synovial fluid samples from 30 patients classified as control (n = 4), early OA (n = 11), and late OA (n = 18). There are significant increases in MPO levels of patients in the early OA group. The data is presented as the mean ± SD of a set of experiments repeated at least two times. Statistical significance of the differences between Control and Early OA (a), and control and late OA (b) was determined by a pairwise comparison of correlated groups using a Student's t-test, and statistical significance is defined as p < 0.005. A two-way ANOVA analysis for correlations between age and MPO levels showed that although the development of OA was age related, the amount of MPO was unrelated to the age of the individual.