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. Author manuscript; available in PMC: 2011 Sep 24.
Published in final edited form as: J Nat Prod. 2010 Sep 24;73(9):1553–1558. doi: 10.1021/np100406d

Table 3.

Cytotoxic Activity of Quassinoids 1–6

ED50 (µM)a
compound DU145 A549 KB KB-VIN
1 0.04 0.06 0.05 0.42
2 0.07 0.07 0.07 0.44
3 0.47 0.88 0.44 1.24
4 0.09 0.13 0.18 0.37
5 0.83 3.6 0.67 NAb
6 4.7 16 4.3 NA
paclitaxel 0.003 0.008 0.007 >1
a

Values are the mean ED50 (concentrations that gave 50% effect under the defined assay condition) in µM.

b

Tested compounds did no reach 50% inhibition at 10 µg/mL.