Table 2.

Parameters used for the human PBPK model.

Parameter	Symbol	Nicotine	Cotinine	Unit
Hepatic intrinsic clearance	CLh,int	755	20.6	L/h
Renal clearance	CLr	4.25	0.180	L/h
Volume of systemic circulation	V1	209	127	L
Hepatic volume	Vh	1.50	1.50	L
Hepatic blood flow rate systemic circulation to the tissue compartment	Qh	96.6	96.6	L/h
Absorption rate constant	ka	0.795	-	h−1
Dose	Dose	70	-	mg

Other parameters are the same as those shown in Table 1 for the rat PBPK model.