Table.
Case | Endocrinopathy | Time From DHSa | Drug Therapyb | Antibodies | Comments |
---|---|---|---|---|---|
114 | Fulminant diabetes | 2 wk | Carbamazepine | Islet cell/GAD negative | |
215 | Fulminant diabetes | 0 d | Mexiletine | GAD negative | Preexisting type 2 diabetes mellitus, concurrent pancreatitis |
316 | Fulminant diabetes | 7 d | Allopurinol | Not reported | Concurrent pancreatitis |
417 | Fulminant diabetes | 2.5 mo | Penicillin, diclofenac, ibuprofen | Islet cell/GAD negative | |
518 | Type 1 diabetes mellitus | 4 mo | Methimazole | GAD positive | |
6 | Type 1 diabetes mellitus | 7 mo | Minocycline | GAD positive, IA2 positive | Our patient |
719 | Hyperthyroidism | 0 d | Minocycline | TPO, TG, TSI negative | Lupuslike syndrome, not DRESS |
820 | Hypothyroidism | 4 wk | Phenytoin | TPO positive | |
920 | Hypothyroidism | 4 wk | Salazopyrin | TPO positive | |
1020 | Hypothyroidism | 8 wk | Phenobarbital | TPO positive | |
1120 | Hypothyroidism | 8 wk | Phenobarbital, carbamazepine | unknown | |
1220 | Hypothyroidism | Unknown | Phenytoin, phenobarbital, carbamazepine | TPO negative | |
13 | Hyperthyroidism | 7 wk | Minocycline | TPO, TG, TSI, TSHR positive | Our patient |
Abbreviations: DRESS, drug reaction with eosinophilia and systemic symptoms; GAD, glutamic acid decarboxylase; TG, thyroglobulin; TPO, thyroid peroxidase; TSHR, thyrotropin-receptor; TSI, thyroid-stimulating immunoglobulin.
Time between presentation of DHS and presentation of endocrinopathy.
Minocycline administered as minocycline hydrochloride.