Table.

Reported Cases of Thyroid Disease and Diabetes Following Drug Hypersensitivity Syndrome (DHS)

Case	Endocrinopathy	Time From DHSa	Drug Therapyb	Antibodies	Comments
114	Fulminant diabetes	2 wk	Carbamazepine	Islet cell/GAD negative
215	Fulminant diabetes	0 d	Mexiletine	GAD negative	Preexisting type 2 diabetes mellitus, concurrent pancreatitis
316	Fulminant diabetes	7 d	Allopurinol	Not reported	Concurrent pancreatitis
417	Fulminant diabetes	2.5 mo	Penicillin, diclofenac, ibuprofen	Islet cell/GAD negative
518	Type 1 diabetes mellitus	4 mo	Methimazole	GAD positive
6	Type 1 diabetes mellitus	7 mo	Minocycline	GAD positive, IA2 positive	Our patient
719	Hyperthyroidism	0 d	Minocycline	TPO, TG, TSI negative	Lupuslike syndrome, not DRESS
820	Hypothyroidism	4 wk	Phenytoin	TPO positive
920	Hypothyroidism	4 wk	Salazopyrin	TPO positive
1020	Hypothyroidism	8 wk	Phenobarbital	TPO positive
1120	Hypothyroidism	8 wk	Phenobarbital, carbamazepine	unknown
1220	Hypothyroidism	Unknown	Phenytoin, phenobarbital, carbamazepine	TPO negative
13	Hyperthyroidism	7 wk	Minocycline	TPO, TG, TSI, TSHR positive	Our patient

Abbreviations: DRESS, drug reaction with eosinophilia and systemic symptoms; GAD, glutamic acid decarboxylase; TG, thyroglobulin; TPO, thyroid peroxidase; TSHR, thyrotropin-receptor; TSI, thyroid-stimulating immunoglobulin.

^aTime between presentation of DHS and presentation of endocrinopathy.

^bMinocycline administered as minocycline hydrochloride.