Skip to main content
. Author manuscript; available in PMC: 2010 Oct 14.
Published in final edited form as: Psychopharmacology (Berl). 2010 Jun 29;211(4):443–455. doi: 10.1007/s00213-010-1914-8

Fig. 3.

Fig. 3

LY354740 pretreatment has no effect on dopamine release and locomotion elicited by electrical stimulation of the VTA. Rats were given an IP injection of 10.0 mg/kg of LY354740 (filled circles)or 0.9% saline (open circles) 20 min prior to electrical stimulation of the VTA. Dopamine release in the a NAc (LY354740 group, n=8; mean baseline dopamine=0.8±0.2 fmol/μL; saline group, n=9; mean baseline dopamine=0.6±0.2 fmol/μL) and locomotor activity were measured in each animal. Activity is expressed in terms of b fine movements (LY354740 group, n=8; saline group, n=9) or c ambulations (LY354740 group, n=8; saline group, n=9). d Peak fine movements were significantly correlated to peak NAc dopamine release. A nonsignificant trend toward a correlation was found between e peak ambulations and peak NAc dopamine release. In graphs A, B and C, baseline dopamine release or locomotor activity are represented by the first three time points displayed. Plus signs denote significant increases in dopamine release or activity compared to baseline (+ p<0.05; ++ p<0.01)