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MGMT silencing may be a useful mark for predicting the prognosis and efficacy of treatment of glioma patients treated with temozolomide. A) A diagram depicting different grades of gliomas highlighting both genetic and epigenetic changes that contribute to tumorigenesis. B) The silencing of MGMT, a protein involved in DNA repair, is associated with poor prognosis and may serve as a predictive factor for TMZ treatment.
