Effect of heterozygous loss of Fst on muscle mass. Bottom panel shows percent decrease in muscle weights in Fst+/− mice compared with wild-type mice. Middle panel shows percent decrease in muscle weights in Fst+/−, Mstn+/− mice compared with Fst+/+, Mstn+/− mice. Top panel shows percent decrease in muscle weights in Fst+/−, Mstn−/− mice compared with Fst+/+, Mstn−/− mice. All calculations were made from the data shown in Table 1. Muscles analyzed were: pectoralis (red), triceps (gray), quadriceps (blue), and gastrocnemius (green).