Table 1.
Muscle weights of mutant mice
| Body weight (g) | Muscle weights (mg)
|
|||||
|---|---|---|---|---|---|---|
| Pectoralis | Triceps | Quadriceps | Gastrocnemius | |||
| Males | ||||||
| Wild type | (n = 36) | 24.0 ± 0.3 | 74.5 ± 1.0 | 94.8 ± 1.2 | 193.3 ± 2.5 | 137.5 ± 1.7 |
| Fst+/− | (n = 15) | 23.3 ± 0.7 | 60.7 ± 1.0a | 78.3 ± 1.4a | 157.4 ± 3.0a | 118.2 ± 2.0a |
| Fstl3−/− | (n = 23) | 25.3 ± 0.6 | 77.2 ± 1.7 | 97.9 ± 1.6 | 200.7 ± 3.8 | 138.2 ± 2.1 |
| Mstn+/− | (n = 17) | 27.6 ± 0.4 | 97.4 ± 1.6 | 123.2 ± 2.4 | 252.6 ± 4.5 | 181.2 ± 3.9 |
| Mstn+/−, Fst+/− | (n = 12) | 26.0 ± 0.4b | 79.3 ± 1.5c | 100.0 ± 2.0c | 197.8 ± 5.3c | 147.4 ± 3.2c |
| Mstn−/− | (n = 8) | 33.8 ± 0.9 | 215.1 ± 7.9 | 231.8 ± 7.3 | 407.1 ± 12.1 | 302.0 ± 10.3 |
| Mstn−/−, Fst+/− | (n = 10) | 31.0 ± 1.3 | 174.3 ± 10.0d | 206.7 ± 10.4 | 352.6 ± 17.3e | 274.4 ± 13.4 |
| inhβA+/− | (n = 21) | 25.0 ± 0.4f | 80.8 ± 1.2a | 104.0 ± 1.6a | 215.0 ± 3.8a | 152.3 ± 2.2a |
| inhβB+/− | (n = 13) | 24.3 ± 0.5 | 73.5 ± 1.7 | 95.8 ± 2.5 | 190.1 ± 3.9 | 134.6 ± 2.2 |
| inhβB−/− | (n = 15) | 24.7 ± 0.4 | 78.9 ± 1.7f | 100.4 ± 2.5f | 201.3 ± 5.0 | 139.1 ± 2.9 |
| inhβC+/−, βE+/− | (n = 12) | 24.8 ± 1.2 | 76.2 ± 3.3 | 95.8 ± 2.6 | 192.2 ± 8.3 | 133.9 ± 5.7 |
| inhβC−/−, βE−/− | (n = 18) | 25.0 ± 0.4f | 76.9 ± 1.3 | 96.8 ± 1.9 | 196.9 ± 3.3 | 138.6 ± 2.0 |
| Females | ||||||
| Wild type | (n = 22) | 19.0 ± 0.2 | 48.3 ± 0.8 | 69.5 ± 0.9 | 146.2 ± 1.8 | 102.5 ± 1.2 |
| Fst+/− | (n = 14) | 17.2 ± 0.4a | 39.1 ± 0.9a | 56.6 ± 1.0a | 115.2 ± 2.0a | 84.7 ± 1.7a |
| Fstl3−/− | (n = 29) | 19.1 ± 0.3 | 50.6 ± 0.8f | 72.5 ± 0.9f | 149.4 ± 1.8 | 100.7 ± 1.1 |
| Fst+/−, Fstl3+/− | (n = 9) | 16.3 ± 0.5a | 37.3 ± 1.6a | 57.0 ± 2.2a | 113.9 ± 4.6a | 82.9 ± 2.8a |
| Fst+/−, Fstl3−/− | (n = 7) | 16.9 ± 0.6g | 36.9 ± 1.4a | 57.3 ± 1.5a | 116.1 ± 4.0a | 80.3 ± 2.6a |
| Mstn+/− | (n = 13) | 22.0 ± 0.4 | 64.2 ± 1.0 | 90.5 ± 1.1 | 185.1 ± 2.3 | 130.5 ± 1.8 |
| Mstn+/−, Fst+/− | (n = 10) | 20.6 ± 0.4h | 52.3 ± 1.3c | 74.6 ± 2.0c | 152.6 ± 3.5c | 111.7 ± 2.2c |
| Mstn−/− | (n = 13) | 24.5 ± 0.4 | 111.0 ± 2.3 | 148.5 ± 1.8 | 276.8 ± 4.2 | 195.8 ± 2.4 |
| Mstn−/−, Fst+/− | (n = 17) | 24.3 ± 0.3 | 94.4 ± 1.6i | 139.2 ± 1.6i | 251.2 ± 3.4i | 186.9 ± 2.4e |
| inhβA+/− | (n = 20) | 19.4 ± 0.2 | 52.4 ± 0.9a | 73.3 ± 1.3f | 155.3 ± 2.2g | 109.3 ± 1.7g |
| inhβB+/− | (n = 15) | 19.8 ± 0.4 | 50.5 ± 0.8f | 70.0 ± 1.2 | 147.5 ± 2.7 | 100.8 ± 1.8 |
| inhβB−/− | (n = 12) | 20.0 ± 0.6 | 51.8 ± 1.4f | 69.9 ± 1.2 | 144.3 ± 3.3 | 100.8 ± 2.2 |
| inhβC+/−, βE+/− | (n = 15) | 18.5 ± 0.7 | 49.2 ± 1.5 | 69.4 ± 2.3 | 141.0 ± 5.5 | 97.5 ± 4.5 |
| inhβC−/−, βE−/− | (n = 25) | 19.1 ± 0.2 | 49.9 ± 0.9 | 70.5 ± 1.0 | 150.4 ± 2.1 | 103.0 ± 1.4 |
a
P < 0.001 vs. wild type;
b
P < 0.01 vs. Mstn+/−;
c
P < 0.001 vs. Mstn+/−;
d
P < 0.01 vs. Mstn−/−;
e
P < 0.05 vs. Mstn−/−;
f
P < 0.05 vs. wild-type;
g
P < 0.01 vs. wild type;
h
P < 0.05 vs. Mstn+/−;
i
P < 0.001 vs. Mstn−/−.