Figure 7.

A working model for NCOA1 and NCOA3 functions in labyrinth morphogenesis. Arrows indicate downstream developmental events or positive regulatory effects. Dashed lines indicate regulatory events without clear molecular mechanisms at this time. The question mark indicates that the cell lineage origin of S-TGC is contentious. Eomes is a marker gene of the labyrinth progenitors. Ctsq is a marker gene of Layer I sinusoidal trophoblast giant cells (S-TGC). Syna is a marker gene of Layer II syncytiotrophoblasts. Gcm1, CEBPα, and Synb are marker genes of Layer III syncytiotrophoblasts. Flk1 and PECAM are markers of endothelia. CoA, indicates that NCOA1 and NCOA3 are coactivators of PPARγ.