Skip to main content
. 2010 Aug 4;24(10):2065–2069. doi: 10.1210/me.2010-0216

Figure 3.

Figure 3

A, Orphan NRs are key regulators of gene expression in metabolic organs. Tissues with critical roles in the regulation of energy metabolism [liver, central nervous system, cardiovascular, fat, pancreas, gastrointestinal (GI) tract, and other metabolic tissues, such as kidney, adrenal gland, and bone] constitute nearly 75% of orphan NR-based expression array datasets. Data were compiled from 47 expression array and GWLA datasets in which the function of an orphan NR was experimentally perturbed. Receptors studied were DAX1, SHP, RORα, RORγ, HNF4α, COUPTF-I, ERRα, ERRβ, ERRγ, NUR77, NURR1, and SF-1. Raw data are available in Supplemental data. Datasets for all orphan NRs have been compiled and annotated and are accessible in the Transcriptomics and Cistromics section of the individual Receptor Pages on the NURSA website. B, EDCs are transcriptionally active in female and male reproductive tissues. For details, please see text. Datasets for all EDCs have been compiled and annotated and are accessible in the Transcriptomics and Cistromics section of the individual Receptor and Ligand Pages on the NURSA website. CNS, Central nervous system.