TABLE 1.

Hepatocyte size and autoradiographic labeling

Group	No. of dogs	Days after PCS	TGF-β dose (ng/kg/day)	No. of labeled hepatocytes per 1,000 hepatocytesa		Cell size unitsa
				Left lobe	Right lobe	Left lobe	Right lobe
1	2	No surgery	–	1.55 ± 0.18	1.55 ± 0.08	0.161 ± 0.002	0.160 ± 0.003
2	3	1	–	1.43 ± 0.43	1.36 ± 0.4	0.192 ± 0.02	0.192 ± 0.023
3	3	2	–	6.33 ± 0.82a	6.26 ± 0.64b	0.134 ± 0.008b	0.134 ± 0.009b
4	3	3	–	5.03 ± 0.27b	4.96 ± 0.3b	0.128 ± 0.009b	0.130 ± 0.008b
5	4	4	–	4.4 ± 0.3b	4.2 ± 0.3b	0.095 ± 0.01b	0.096 ± 0.015b
6	3	4	5	2.4 ± 0.5c, d	4.6 ± 0.8	0.064 ± 0.02c, d	0.103 ± 0.01
7	2	4	50	2.1 ± 0.05c, d	4.9 ± 0.7	0.071 ± 0.006c, d	0.106 ± 0.004

PCS = portacaval shunt.

Group 1: dogs that did not undergo surgery; groups 2 to 5: dogs 1 to 4 days after PCS; groups 6 and 7: dogs with PCS and 4-day continuous infusion of TGF-β into the left branch of the portal vein.

^aData expressed as mean ± S.D.

^bp < 0.001 vs. groups 1 and 2.

^cp < 0.01 vs. own right lobe.

^dp < 0.05 vs. left lobe of group 5.