In vivo effects of chlorpyrifos on cholinesterase activity (A, B) and [3H]oxotremorine-M binding (C, D). Rats were treated with vehicle (open bar), 0.5 × LD10 (black bar: 7.5 mg/kg in neonate; 68 mg/kg in adult) or 1 × LD10 (shaded bar: 15 mg/kg, neonate; 136 mg/kg, adult) and sacrificed at the specified times. Data represent percent of control (mean ± SEM). Data for each time point were analyzed individually by ANOVA and Newman-Keuls post hoc test. An asterisk indicates statistically different from control (p< 0.05). A pound sign indicates statistically different from the lower dose group (p< 0.05).