Table 1.
Hours after treatment | |||||
---|---|---|---|---|---|
4 | 24 | 48 | 72 | 96 | |
Control | 2 ± 0 | 2 ± 0 | 2 ± 0 | 2 ± 0 | 2 ± 0 |
68 mg/kg | 2 ± 0 | 3 ± 1 * | 3 ± 1 * | 2.5 ± 0.5 | 2 ± 0.5 |
136 mg/kg | 3 ± 0.5 *# | 3 ± 0 *# | 3 ± 0 * | 2.5 ± 0 * | 2 ± 0.5 |
Rats were treated with vehicle, 0.5 × LD10 (68 mg/kg) or 1 × LD10 (136 mg/kg). Rats were observed for involuntary movements and scored according to the protocol described in the Materials and Methods section. Data represent median ± inter-quartile range. Data were analyzed using MANOVA (JMP statistical package).
Asterisks represent values statistically different from respective controls (p< 0.05).
Pound signs represent values statistically different from the low dose group (p< 0.05).