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Cut-points for the optimal diagnosis of Cushing’s syndrome, the resultant sensitivity and specificity, and the area under the curve (AUC).
| Test | Cut-point | Sensitivity | Specificity | AUC | NPV | PPV |
|---|---|---|---|---|---|---|
| total testosterone (nmol/L) | 1.39 | 95% | 70% | 0.87 | 0.93 | 0.76 |
| bioavailable testosterone (nmol/L) | 0.24 | 75% | 80% | 0.77 | 0.80 | 0.75 |
| FAI | 5.7 | 88% | 60% | 0.79 | 0.80 | 0.69 |
Positive predictive value (PPV) and negative predictive value (NPV) are also depicted for each study
