Table 1.
Effect of caloric restriction on serum and tissue biochemistry of 6-month-old LCR rats
| LCR
|
HCR AL | ||
|---|---|---|---|
| AL | CR | ||
| Initial body weight (g) | 402. ± 12.6 | 412. ± 9.61 | 274. ± 8.41a,c |
| Body eeight at sacrifice (g) | 471. ± 8.29 | 335. ± 6.99b | 340. ± 9.81a |
| Initial daily food consumption (g) | 17.5 ± 0.64 | 17.5 ± 0.64 | 14.6 ± 0.65a,c |
| Total daily food consumption (g) | 21.5 ± 0.52 | 12.3 ± 0.45b | 19.3 ± 0.55c |
| %Visceral fat/body weight | 1.81 ± 0.11 | 0.81 ± 0.12b | 1.11 ± 0.11a |
| Hepatic triglyceride (μg/mg protein) | 154. ± 20.5 | 67.8 ± 14.4b | 96.7 ± 13.8a |
| Fasting blood glucose (mg/dl) | 121. ± 6.14 | 106. ± 3.38b | 103. ± 4.54a |
| Random blood glucose (mg/dl) | 100. ± 3.10 | 86.8 ± 4.70b | 87.3 ± 3.26a |
| Serum insulin (pm) | 794. ± 156. | 115 ± 12.2b | 201. ± 31.8a,c |
| Serum C-peptide (pm) | 2655 ± 259.0 | 940 ± 133b | 1397 ± 145.0a,c |
| Serum C-peptide/insulin molar ratio | 4.66 ± 0.84 | 8.23 ± 0.62b | 7.81 ± 0.63a |
| Serum FFA (mEq/liter) | 1.46 ± 0.11 | 0.70 ± 0.20b | 0.79 ± 0.07a |
| Serum triglyceride (mg/dl) | 53.1 ± 7.32 | 18.7 ± 3.05b | 31.9 ± 3.96a,c |
Male LCR (n > 8 per group; 3 months of age) were fed AL or CR for 3 months prior to blood drawing from tail vein and tissue extraction at the time of killing for biochemical analysis. Age-matched (6-month-old) AL-HCR were also examined. Values are expressed as mean ± sem.
a
P < 0.05 AL-HCR vs. AL-LCR.
b
P < 0.05 CR-LCR vs. AL-LCR.
c
P < 0.05 AL-HCR vs. CR-LCR.