Figure 1.
P treatment inhibits the diurnal estradiol-mediated increase in ICa in GnRH neurons. A, Representative recordings showing activation of ICa in GnRH neurons from OVXE (left) and OVXEP (right) mice in the morning (top) and afternoon (bottom). For clarity, only four voltage steps during the test pulse (−80, −10, 0, and 10 mV) are shown (bottom left). B and C, Average I-V curves of peak current from GnRH neurons in the morning (B) and afternoon (C). *, P < 0.05, OVXE vs. OVXEP, and OVX vs. OVXE. D and E, Activation (D) and steady-state inactivation (E) curves in the morning and afternoon. F and G, Rise and decay time.