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. Author manuscript; available in PMC: 2010 Oct 14.
Published in final edited form as: Transplant Proc. 1993 Feb;25(1 Pt 1):511–512.

Table 1.

Nonimmunologic Profile (4 + Worst) (All Dose Related)

FK 506 CyA
Nephrotoxicity ++* ++
Neurotoxicity + +
Diabetogenicity + +
Growth effects
   Hirsutism 0 +++
   Gingival hyperplasia 0 ++
   Facial brutilization 0 +
   Hepatotrophic effects ++++ +++
   Gynecomastia 0 +
Other metabolic effects
   Cholesterol increase 0† ++
   Uric acid increase +? ++

Reprinted with permission.2

*

Less hypertension.

†

In rats, Van Thiel has shown an increase in cholesterol synthesis and serum concentration.