Table 3. Top 10 TF binding sites overrepresented in genes regulated at 48 hr.
| WT | DKO | ||||||
| Hippocampus | Amygdala | Hippocampus | Amygdala | ||||
| TF binding site | P-value | TF binding site | P-value | TF binding site | P-value | TF binding site | P-value |
| Upregulated | |||||||
| Pou6f1 | 2.3E-11 | Areb6 | 7.4E-04 | N/A | N/A | ||
| Pou1f1 | 2.5E-11 | Lfa1 | 1.3E-03 | ||||
| Tef | 4.4E-11 | E12 | 3.5E-03 | ||||
| Crebatf | 4.5E-09 | Gata2 | 3.8E-03 | ||||
| Gata3 | 1.9E-08 | Hoxa7 | 5.1E-03 | ||||
| Dr3 | 1.5E-07 | Pbx1 | 5.4E-03 | ||||
| Amef2 | 1.7E-07 | Foxp3 | 5.8E-03 | ||||
| Hp1sitefactor | 6.0E-07 | ||||||
| Hfh3 | 7.3E-07 | ||||||
| Atf | 1.0E-06 | ||||||
| Downregulated | |||||||
| Pads | 1.6E-04 | Lhx3 | 8.9E-10 | TfIIa * | 1.3E-07 | E47 | 3.6E-05 |
| Meis1 | 2.5E-04 | Cart1 | 2.4E-08 | Foxo1 * | 9.4E-07 | Areb6 | 8.2E-04 |
| TfIIa | 3.8E-04 | Pou6f1 | 3.4E-08 | Gata3 | 1.9E-05 | Cmyb | 2.3E-03 |
| Hp1sitefactor | 1.3E-03 | Sox5 | 9.6E-08 | Foxo4 * | 3.9E-05 | Crebp1cjun | 5.0E-03 |
| Gata1 | 2.7E-03 | Sox9 | 5.2E-07 | Lef1tcf1 | 4.8E-05 | Nmyc | 5.1E-03 |
| Areb6 | 3.1E-03 | Hif1 | 6.7E-07 | Dr3 | 9.3E-05 | ||
| Nkx61 | 1.0E-06 | Hp1sitefactor | 1.6E-04 | ||||
| Hp1sitefactor | 2.2E-06 | Foxp3 * | 2.8E-04 | ||||
| Vbp | 2.8E-06 | Hfh4 * | 4.3E-04 | ||||
| Gata3 | 2.9E-06 | Lhx3 * | 7.2E-04 | ||||
The 2.5kbp region upstream region of genes modulated during CF learning was assessed for common transcription factor (TF) binding sites. The significance value takes into consideration the total number of sites in the genes analyzed versus the total number of sites in the whole genome. Bold genes represent TF binding sites in DKO mice that are significantly upregulated within each respective WT brain region, while.
*indicates TF binding sites that are significantly upregulated in WT mice, but do not make the top ten list.