Table 5. Detection performance of CDAs that target ARI.

		Case-Detection Algorithm Number
Category	Subcategory	1	2	3	4	5	6	7	8	9
CDA Component	BioSense ICD-9 Codes	•
	Essence ICD-9 Codes		•
	VA ICD-9 Codes			•	•	•	•	•	•	•
	OR Temperature ≥38°C				•				•	•
	OR Blood Culture					•		•
	OR Cough Remedies						•	•	•	•
	OR CBC/Diff									•
	OR Gram stain									•
Maryland Site	Sensitivity	61	68	78	81	81	84	87	87	87
	Specificity	94	97	96	96	95	95	94	94	93
	Positive Predictive Value	23	37	36	35	33	31	30	30	27
	Area under the ROC	78	83	87	89	88	90	91	91	90
Utah Site	Sensitivity	64	74	80	80	80	85	85	86	87
	Specificity	91	98	97	97	97	96	95	95	92
	Positive Predictive Value	9	29	27	25	25	20	20	19	13
	Area under the ROC	78	86	89	89	89	91	90	91	90

Composition (black dot indicates that the component is included in the CDA) of ARI CDAs that combine parameters derived from structured EMR entries. Statistical performance can be compared at each study site.