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. 2010 Oct 14;6(10):e1001157. doi: 10.1371/journal.pgen.1001157

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This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

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Circles represent haplotypes, with the areas proportional to the frequency of the haplotype (color-coded by population). The lines connecting the haplotypes have a length proportional to the number of mutations that differentiate the two haplotypes. Reticulations reflect recombinations or recurrent mutations. The ancestral state was inferred using the chimpanzee sequence data. For ERAP2, the four coding diagnostic SNPs are shown as white boxes; one nearly diagnostic SNP, which appears four times in the network due to the reticulations, is marked as thinner horizontal boxes. The ERAP2 haplotype network that includes all SNPs (coding and non-coding) is shown in Figure S5, and the ERAP2 haplotype network that includes the chimpanzee sequence is shown in Figure S6.