Table 4.
Logistic regression-derived odds ratios (ORs) and 95% confidence intervals (95% CIs) for the risk of myocardial infarction (MI) by eNOS E298D, controlling for demographic and medical history variables among the 422 study participants
| Variable | Category or increment | ORs1 (95% CIs) | ORs2 (95% CIs) | ORs3 (95% CIs) | ORs4 (95% CIs) | ORs5 (95% CIs) |
|---|---|---|---|---|---|---|
| p-value | p-value | p-value | p-value | p-value | ||
| eNOS E298D | TT vs. GT+GG | 2.06 (1.06-4.00) | 2.04 (1.05-3.96) | 2.41 (1.18-4.92) | 2.57 (1.18-5.60) | 2.89 (1.11-7.51) |
| 0.032 | 0.036 | 0.016 | 0.018 | 0.029 | ||
| Age | 60+ vs. < 60 years | 1.11 (0.75-1.65) | 1.76 (1.13-2.75) | 2.24 (1.38-3.64) | 1.00 (0.54-1.80) | |
| 0.602 | 0.013 | 0.001 | 0.969 | |||
| Gender | female vs. male | 0.86 (0.48-1.53) | 1.26 (0.67-2.37) | 1.19 (0.62-2.30) | 1.37 (0.66-2.87) | |
| 0.606 | 0.470 | 0.608 | 0.401 | |||
| BMI | 2 kg/m2 more | 1.14 (1.00-1.30) | 1.13 (0.98-1.30) | 1.12 (0.97-1.30) | ||
| 0.057 | 0.096 | 0.132 | ||||
| Smoking | yes vs. no | 4.93 (2.98-8.15) | 5.53 (3.21-9.54) | 6.83 (3.64-12.84) | ||
| < 0.0001 | < 0.0001 | < 0.0001 | ||||
| Family history of CAD | yes vs. no | 6.97 (3.98-12.21) | 6.91 (3.69-12.94) | |||
| < 0.0001 | < 0.0001 | |||||
| Hypertension | yes vs. no | 11.91 (6.70-21.17) | ||||
| < 0.0001 |
1 = Model 1: Unadjusted odds ratio for eNOS E298D
2 = Model 2: Odds ratio for mutually adjusted eNOS E298D, age and gender
3 = Model 3: Odds ratio for mutually adjusted eNOS E298D, age, gender, BMI and smoking
4 = Model 4: Odds ratio for mutually adjusted eNOS E298D, age, gender, BMI, smoking and family history of CAD
5 = Model 5: Odds ratio for mutually adjusted eNOS E298D, age, gender, BMI, smoking, family history of CAD and hypertension