Table 2.
Comparison between immunohistochemistry, CISH and FISH in 33 cell blocks from lung FNAC
| IHC score | N° of cases | CISH | FISH | ||||||
|---|---|---|---|---|---|---|---|---|---|
| D | T | P | A | D | T | P | A | ||
| 0 | 9 | 1 | 5 | 3 | 0 | 2 | 2 | 5 | 0 |
| 1+ | 3 | 1 | 0 | 2 | 0 | 0 | 0 | 3 | 0 |
| 2+ | 5 | 1 | 0 | 4 | 0 | 0 | 0 | 5 | 0 |
| 3+ | 16 | 2 | 7 | 6 | 2 | 2 | 5 | 6 | 3 |
| Total | 33 | 5 | 12 | 14 | 2 | 4 | 7 | 19 | 3 |
IHC: immunohistochemistry; CISH: chromogenic in situ hybridization; FISH: fluorescence in situ hybridization;
D: disomy, 1.6-2.0 balanced gene and chromosome 7; T: trisomy, 2.2-3.0 balanced gene and chromosome 7; P: polysomy, 3.1-4.4 balanced gene and chromosome 7; A: amplified, gene-to-chromosome 7 ratio ≥2
Sensitivity 60%; Specificity 89%; Positive predictive value 50%; Negative predictive value 93%