Table 2.
Composition (weight %) and distribution (%) of HDL derived from the low-HDL-C and control subjects
| Low-HDL-C | Control | P | |
|---|---|---|---|
| HDL2 particle mass (mg/dl) | 68 (58 - 90) | 153 (106 - 213) | < 0.0001 |
| HDL2 CE/TG ratio | 3.17 (2.64 - 4.22) | 6.00 (4.48 - 7.34) | < 0.0001 |
| HDL2 TG (% of HDL2) | 5.6 (4.2 - 6.6) | 3.4 (2.8 - 4.5) | < 0.0001 |
| HDL2 CE (% of HDL2) | 18.9 (16.2 - 20.6) | 20.8 (19.2 - 22.3) | 0.002 |
| HDL2 free cholesterol (% of HDL2) | 4.7 (4.2 - 6.0) | 5.0 (4.6 - 5.6) | 0.573 |
| HDL2 phospholipids (% of HDL2) | 24.0 (22.0 - 26.0) | 27.9 (24.8 - 29.5) | 0.001 |
| HDL2 protein (% of HDL2) | 46.3 (43.1 - 49.4) | 42.5 (39.9 - 46.2) | 0.0007 |
| HDL3 particle mass (mg/dl) | 209 (191 -226) | 242 (214 - 266) | 0.0001 |
| HDL3 CE/TG ratio | 4.64 (3.48 - 5.96) | 7.07 (5.61 - 8.80) | < 0.0001 |
| HDL3 TG (% of HDL3) | 3.7 (3.0 - 4.3) | 2.5 (2.1 - 3.1) | < 0.0001 |
| HDL3 CE (% of HDL3) | 16.8 (14.9 - 18.8) | 17.5 (16.5 - 19.1) | 0.039 |
| HDL3 free cholesterol (% of HDL3) | 2.3 (2.0 - 2.5) | 2.4 (2.2 - 2.6) | 0.848 |
| HDL3 phospholipids (% of HDL3) | 22.2 (20.2 - 23.3) | 22.3 (21.0 - 23.2) | 0.815 |
| HDL3 protein (% of HDL3) | 54.9 (51.6 - 58.1) | 55.6 (51.7 - 57.7) | 0.984 |
| HDL2b (%) | 15.1 ± 5.0 | 30.1 ± 10.4 | < 0.0001 |
| HDL2a (%) | 27.2 ± 5.2 | 26.3 ± 7.0 | 0.763 |
| HDL3a (%) | 34.9 ± 4.4 | 27.7 ± 6.4 | < 0.0001 |
| HDL3b (%) | 18.5 ± 5.4 | 10.9 ± 4.5 | < 0.0001 |
| HDL3c (%) | 5.3 ± 2.7 | 4.1 ± 3.0 | 0.422 |
| HDL mean particle size (nm) | 8.98 ± 0.21 | 9.44 ± 0.35 | < 0.0001 |
Data are expressed as means ± SD or median (lower and upper quartile). TG: triglycerides, CE: cholesteryl esters. Statistical significances were adjusted for age, sex, and smoking status. HDL subclasses were isolated by ultracentrifugation and distribution of HDL subclasses as well as particle size were analyzed by native gradient gel electrophoresis.