Table 1.
Associations of GHRL and GHSR polymorphisms with colorectal cancer risk in the Czech population
| Casesa | Controlsa | OR(95%)b | P value | P trend | |
|---|---|---|---|---|---|
| GHRL | |||||
| rs26802 | |||||
| G/G | 286 | 278 | 1 | ||
| G/T | 294 | 245 | 1.18(0.92-1.51) | 0.18 | |
| T/T | 93 | 74 | 1.19(0.82-1.70) | 0.25 | 0.16 |
| rs27647 | |||||
| C/C | 279 | 198 | 1 | ||
| C/T | 289 | 280 | 0.70(0.55-0.91) | 0.008 | |
| T/T | 93 | 110 | 0.57(0.40-0.80) | 0.002 | 0.001 |
| rs35683 | |||||
| A/A | 204 | 147 | 1 | ||
| A/C | 331 | 297 | 0.80(0.61-1.05) | 0.11 | |
| C/C | 137 | 143 | 0.71(0.51-0.98) | 0.04 | 0.02 |
| rs4684677 | |||||
| A/A | 601 | 523 | 1 | ||
| A/C | 78 | 74 | 0.91(0.64-1.30) | 0.49 | |
| C/C | 4 | 3 | 1.63(0.35-7.68) | 0.62 | 0.70 |
| rs696217 | |||||
| G/G | 590 | 523 | 1 | ||
| G/T | 84 | 71 | 1.09(0.77-1.55) | 0.64 | |
| T/T | 4 | 6 | 0.60(0.16-2.18) | 0.43 | 0.89 |
| rs2075356 | |||||
| C/C | 559 | 498 | 1 | ||
| C/T | 101 | 78 | 1.20(0.86-1.68) | 0.63 | |
| T/T | 7 | 7 | 0.88(0.30-2.61) | 0.36 | 0.28 |
| rs35684 | |||||
| A/A | 257 | 248 | 1 | ||
| A/G | 213 | 174 | 1.10(0.84-1.43) | 0.46 | |
| G/G | 47 | 34 | 1.24(0.77-2.00) | 0.36 | 0.29 |
| GHSR | |||||
| rs2922126 | |||||
| T/T | 255 | 20 | 1 | ||
| A/T | 269 | 274 | 0.81(0.62-1.05) | 0.11 | |
| A/A | 74 | 39 | 1.48(0.95-2.30) | 0.82 | 0.31 |
| rs2944694 | |||||
| A/A | 564 | 477 | |||
| A/G | 98 | 101 | 0.78(0.57-1.07) | 0.14 | |
| G/G | 7 | 11 | 0.46(0.16-1.28 | 0.14 | 0.08 |
| rs495225 | |||||
| A/A | 333 | 293 | 1 | ||
| A/G | 232 | 220 | 0.88 (0.68-1.13) | 0.33 | |
| G/G | 58 | 42 | 1.17(0.75-1.83) | 0.47 | 0.77 |
| rs572169 | |||||
| C/C | 329 | 305 | 1 | ||
| C/T | 263 | 235 | 1.03(0.80-1.31) | 0.80 | |
| T/T | 57 | 48 | 1.14(0.74-1.74) | 0.55 | 0.62 |
a Numbers may not add up to 100% of subjects due to genotyping failure. All samples that did not give a reliable result in the first round of genotyping were resubmitted to up to two additional rounds of genotyping. Data points that were still not filled after this procedure were left blank.
b OR: odds ratio; CI: confidence interval. Adjusted for age and gender. Results in bold are statistically significant (p < 0.05)