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Insertion of the CLOCK gene but not of mutant CLOCK gene enhances the replication of ΔICP0 mutant virus. Vero (A and C) or HEL (B and D) cells were exposed to 0.1 pfu per cell to ΔICP0 virus (None, A–D), the R6703 ΔICP0 virus carrying the CLOCK gene (CLOCK, all panels), the R6704 ΔICP0 virus carrying the mutated CLOCK (mCLOCK, C and D) or the R6705 ΔICP0 virus carrying the Bmal1 gene (Bmal1, A and B). The viruses harvested at 6, 24, or 48 h after infection were titered on U2OS cells.
