Fig. 1.

Measurements of ¹¹C-PIB BP (displayed on the y axis) were performed in 11 individuals with DAT (A) and in 14 cognitively normal community-dwelling individuals (B) and, in both cases, were compared with the level of aerobic glycolysis measured in 33 neurological control individuals (x axis). The level of aerobic glycolysis (GI) represents the amount of glucose consumption above or below that predicted by the amount of oxygen. (Further details are given in the text and in ref. 12.) These data were obtained from 167 nonoverlapping isotropic cubes covering the whole brain that were normalized to the ¹¹C-PIB binding potential cerebellum. (C) The difference between ¹¹C-PIB values in DAT and cognitively normal groups was calculated and plotted against the GI. The strong positive correlation indicates that, although the regional pattern of Aβ distribution remains similar, the slopes of the relationships depicted in A and B differ significantly (P < 10⁻⁴).