Table 1.

Model features and accuracy in predicting KO phenotypes in each organism

Feature	E. coli	M. tuberculosis
Metabolic model	IAF1260	iNJ661
Metabolic reactions	2,382	1,028
Regulatory data	RegulonDB	Balazsi et al. (27)
Regulatory interactions	1,773	218
Microarrays	907	437
Total genes in the model	1,400	691
Validation data set	1,875 growth phenotypes	30 TF KO
Accuracy, %	85	95
Sensitivity, %	70	83
Specificity, %	91	100