Table 3.

Sensitivity and specificity of different combinations of methylation markers

Gene Combinations	AUC	Sensitivity (%)	Specificity (%)
PGP9.5, ESR, DCC, AIM1, and KIF1A	0.87 (0.78–0.95)	92	82
PGP9.5, DLC1, DLEC	0.84 (0.73–0.96)	84	85
PGP9.5, DLEC, DCC, KIF1A	0.89 (0.86–0.96)	90	89
DLEC, DCC, KIF1A, AIM1	0.88 (0.81–0.96)	92	85
PGP9.5, KIF1A	0.85 (0.77– 0.92)	78	92
PGP9.5, DLC1	0.85 (0.77– 0.92)	78	92
PGP9.5, DCC	0.86 (0.78–0.96)	84	89
DLEC, KIF1A	0.87 (0.80–0.93)	78	96
PGP9.5, KIF1A, DLEC	0.88 (0.81–0.95)	84	92
AIM1, DCC	0.79 (0.70–0.88)	70	89
DCC, DLC1	0.81 (0.73–0.88)	66	96
KIF1A, DCC, DLEC	0.89 (0.82–0.96)	86	92

AUC: area under the curve derived from nonparametric ROC curves