Skip to main content
. Author manuscript; available in PMC: 2011 Apr 14.
Published in final edited form as: Nature. 2010 Oct 3;467(7317):849–853. doi: 10.1038/nature09409

Figure 1. ETV1 is universally highly expressed and required for tumour growth and survival in GIST.

Figure 1

a, Venn diagram of GIST-signature genes from three datasets. b, Expression of ETV1 in multiple tumour types from the ExpO dataset. Box, 25–75 percentile; error bar, 10–90 percentile; dots, outliers. c, ETV1 and KIT mRNA levels by qRT-PCR of GIST and non-GIST samples, whose details are described in Full Methods. Mean±SD, n=3. d, Immunoblotting of selected tumour tissues and cell lines from c. e, Growth curves of GIST and U2OS cells after shRNA-mediated ETV1 suppression compared to control. Mean±SEM, n=3. f, Tumour volume over time in SCID mice implanted with GIST882 cells after shRNA-mediated ETV1 suppression compared to scrambled shRNA controls. Mean±SEM, * p<0.05; n=7, 10, 8 for scrambled, ETV1sh1, and ETV1sh2 respectively. g, ETV1 mRNA levels of preimplanted GIST882 cells and explanted xenografts at week 10. Mean±SD.