Fig. 5.
Analysis of gene and microRNA expression by microarrays 7 days after intervention: A+B) number of differentially expressed genes in TAC and Shunt and between both models (n=4 per group). Lower numbers indicated the number of genes with a significant regulation between invervention and sham as well as between both models; A) upregulated genes; B) downregulated genes. C-E) Analysis of microRNA-expression by microarrays (n=5 per group) after 7 days in TAC (■) and Shunt (○). Only microRNAs with a significant different expression between TAC and Shunt are shown (TAC vs. Shunt: * p<0.01, # p<0.02); C) microRNAs significantly regulated in TAC vs. Sham (p<0.01) D) microRNAs significantly regulated in Shunt vs. Sham (p<0.01); E) microRNA significantly regulated in TAC and Shunt to the corresponding sham (p<0.01)