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. 2010 Aug 11;118(1):191–201. doi: 10.1093/toxsci/kfq235

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Published by Oxford University Press 2010.

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FIG. 2. — EM photomicrographs (×30,000 magnification) of liver from infant patas taken: at birth after in utero exposure to human-equivalent protocols containing: no drug (A), AZT/ddI (B), or d4T/3TC (C); and at 1 year after in utero exposure to human-equivalent protocols containing no drug (D), AZT/ddI (E), or d4T/3TC (F) (× 30,000 magnification). The photos show swelling of mitochondria in the NRTI-exposed groups (B, C, E, and F, white arrows); disruption of mitochondrial membranes and dissolution of some cristae with high mitochondrial luminosity (B, C, E, and F, white arrow heads); and clusters (possible clonal expansions) of highly damaged, similar appearing, mitochondria (E and F).