Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2010 Aug 11;118(1):191–201. doi: 10.1093/toxsci/kfq235

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Published by Oxford University Press 2010.

PMC Copyright notice

FIG. 3. — Brain cortex mtDNA (LU/ng total patas DNA, mean ± SE) determined by HC-CA. (A) Patas offspring taken at birth after in utero exposure to no drug (n = 4), 3TC (n = 4), AZT/3TC (n = 3), AZT/ddI (n = 3), or d4T/3TC (n = 3). One-way ANOVA showed significant depletion in the NRTI-treated groups compared with the controls (p = 0.01), and the Holm-Sidak method for multiple comparisons showed significant (p < 0.05) depletion in groups exposed to 3TC and d4T/3TC. (B) Patas offspring taken at 1 year of age after in utero plus 6 weeks post-birth exposure to no drug (n = 4), AZT (n = 4), AZT/3TC (n = 3), AZT/ddI (n = 4), or d4T/3TC (n = 4), followed by 46 weeks with no drug exposure. By one-way ANOVA, all the NRTI-exposed groups were significantly (p < 0.001) depleted compared with the unexposed group. Also, by the Holm-Sidak procedure for multiple comparisons, all NRTI-exposed groups were significantly (p < 0.002) depleted in mtDNA compared with the unexposed group.