TABLE 1.
OXPHOS Complex I, II, and IV Enzyme Activities (nmol/min/mg protein ± SE) in Brain Cortex Mitochondria from Patas Infants Taken at Birth and 1 Year of Age
| NRTI exposure | Age of monkeys | Complex I | Complex II | Complex IV |
| None | Birth (n = 1) | 31.5 | 63.0 | 153.0 |
| 1 year (n = 4) | 75.7 ± 26.74 | 78.1 ± 9.50 | 262.9 ± 92.90 | |
| 3TC | Birth (n = 3) | 24.7 ± 4.00 | 173.1 ± 60.37 | 194.3 ± 37.24 |
| AZT | 1 year (n = 4) | 81.0 ± 28.62 | 68.3 ± 15.31 | 206.4 ± 72.92 |
| AZT/3TC | Birth (n = 1) | 29.4 | 146.6 | 233.6 |
| 1 year (n = 3) | 60.0 ± 24.50 | 62.5 ± 7.67 | 200.6 ± 81.89 | |
| AZT/ddI | Birth (n = 3) | 30.5 ± 1.25 | 128.5 ± 7.02 | 184.7 ± 37.60 |
| 1 year (n = 4) | 74.1 ± 26.18 | 64.7 ± 9.24 | 202.4 ± 71.5 | |
| d4T/3TC | Birth (n = 3) | 31.3 ± 3.00 | 135.5 ± 11.44 | 184.5 ± 15.67 |
| 1 year (n = 3) | 57.6 ± 23.50 | 54.7 ± 5.01 | 227.7 ± 92.94 |