TABLE 3.

Dose-Dependent Incidence and Severity of Hepatic Histopathological Responses in the Vehicle, TCDD-, PCB126-, and TCDF-Treated Mice at 24 h

	Treatment and dose (μg/kg)
	Vehicle	TCDD			PCB126			TCDF
	0	30	100	300	300	1000	3000	300	1000	3000
Hepatocellular vacuolization
Average severity	0	1	1.75	2.5	1	1.5	2	1.25	1.75	2.5
Hepatocellular single cell necrosis
Average severity	0	0	0	0.5	0	0	0.5	0	0	1.25
Mixed cell infiltration
Average severity	0	0.25	0.25	0.5	0	0.5	0.5	0	0.25	0.75

Note. The average severity scores are reported as a weighted average based on the following scoring scheme: minimal (grade of 1), slight (grade of 2), moderate (grade of 3), and/or marked (grade of 4) responses divided by the total number of examined animals. A comprehensive histopathological report with detailed incidence and severity is available in Supplementary table 1.