Table 5.
Validation of liver fibrosis stages classification by liver fibrosis indices
| AUCs (95% CI) | Sensitivity (%) | Specificity (%) | Accuracy (%) | Positive predictive value (%) | Negative predictive value (%) | Positive likelihood ratio | |
| F ≥ 1 (F0 vs F1-2-3-4) | |||||||
| Fibro-Stiffness index | 0.80 (0.712-0.878) | 73.6 | 78.6 | 74.2 | 94.0 | 27.7 | 3.52 |
| Fibro-Stiffness index and AST | Non | 78.3 | 78.6 | 78.3 | 96.5 | 32.4 | 3.64 |
| Liver stiffness | 0.82 (0.727-0.907) | 63.2 | 85.7 | 65.8 | 97.1 | 23.5 | 4.42 |
| APRI | 0.80 (0.704-0.899) | 87.7 | 35.7 | 81.7 | 91.2 | 27.8 | 1.36 |
| Forns index | 0.77 (0.659-0.880) | 72.4 | 71.4 | 72.3 | 95.0 | 25.6 | 2.53 |
| FibroIndex | 0.83 (0.723-0.937) | 89.6 | 50.5 | 85.8 | 93.1 | 38.9 | 1.79 |
| F ≥ 2 (F0-1 vs F2-3-4) | |||||||
| Fibro-Stiffness index | 0.82 (0.750-0.898) | 65.7 | 96.6 | 76.7 | 90.6 | 63.8 | 10.31 |
| Liver stiffness | 0.85 (0.787-0.920) | 76.7 | 83.0 | 79.2 | 87.5 | 69.6 | 4.51 |
| APRI | 0.82 (0.741-0.893) | 50.7 | 89.4 | 65.8 | 88.1 | 53.8 | 4.76 |
| Forns index | 0.78 (0.700-0.864) | 58.3 | 80.9 | 67.2 | 82.4 | 55.9 | 3.05 |
| FibroIndex | 0.79 (0.713-0.875) | 69.5 | 83.0 | 74.2 | 86.2 | 62.9 | 4.02 |
| F ≥ 3 (F0-2 vs F3-4) | |||||||
| Fibro-Stiffness index | 0.93 (0.876-0.986) | 93.9 | 83.9 | 86.7 | 68.9 | 97.3 | 5.84 |
| Liver stiffness | 0.92 (0.871-0.977) | 81.8 | 82.8 | 82.5 | 64.3 | 92.3 | 4.75 |
| APRI | 0.83 (0.753-0.922) | 75.8 | 81.6 | 80.0 | 61.0 | 89.9 | 4.12 |
| Forns index | 0.84 (0.759-0.912 | 78.1 | 71.3 | 73.1 | 50.0 | 90.0 | 2.72 |
| FibroIndex | 0.85 (0.772-0.928) | 76.6 | 80.5 | 80.0 | 60.5 | 90.9 | 4.03 |
| F = 4 (F0-1-2-3 vs F4) | |||||||
| Fibro-Stiffness index | 0.97 (0.934-0.997) | 100 | 84.1 | 85.8 | 43.3 | 100 | 6.29 |
| Fibro-Stiffness index and HA | Non | 100 | 86.9 | 88.3 | 48.1 | 100 | 7.63 |
| Liver stiffness | 0.97 (0.942-0.999) | 100 | 83.2 | 85.0 | 41.9 | 100 | 5.94 |
| APRI | 0.92 (0.867-0.972) | 100 | 75.7 | 78.3 | 33.3 | 100 | 4.12 |
| Forns index | 0.88 (0.798-0.968) | 83.3 | 72.9 | 73.9 | 25.6 | 97.5 | 3.07 |
| FibroIndex | 0.92 (0.874-0.971) | 100 | 77.6 | 80.0 | 35.0 | 100 | 4.46 |
AUCs: Area under the receiver operating characteristics; CI: Confidence interval; HA: Hyaluronic acid; AST: Aspartate aminotransferase; APRI: Aminotransferase-to-platelet ratio index.