Fig. 2.

Targeted ultrasound imaging with annexin A5 conjugated microbubbles in doxorubicin-treated rats (A and B) and control rats (C and D). Significant contrast opacification of myocardium (arrows) was observed in the 1^st frame (A). Initial contrast enhancement was dissipated during subsequent high mechanical index imaging in the 10^th frame (B). No contrast opacification was observed in the myocardium in the 1^st frame (C). No contrast opacification was observed in the myocardium in the 10^th frame (D).