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. Author manuscript; available in PMC: 2011 Aug 1.
Published in final edited form as: Genesis. 2010 Aug;48(8):479–484. doi: 10.1002/dvg.20644

Fig. 1. Deletion of Hand1 in extraembryonic and lateral mesoderm results in embryonic lethality.

Fig. 1

Hand1 was conditionally deleted in lateral and extraembryonic mesoderm using the HoxB6-Cre deleter line and Hand1 expressing tissues were marked using a β-galactosidase gene inserted into the Hand1 gene. (a) Control embryos show the distribution of Hand1 expression at 9.5 dpc. (b) Conditional mutant embryos at 9.5 dpc are developmentally retarded failing to turn and do not develop past the 7-somite stage. ant: anterior, h; heart, lm; lateral mesoderm, post: posterior.